CONDICIONES DE SALUD Cáncer, Leucemia, Inflamación, Artritis, Artrosis, Radicales libres, Sistema inmunológico deprimido, Intoxicación, deterioro del ADN.

ESPECIE Uncaria tomentosa

UBICACIÓN Se encuentra desde Panamá hasta Bolivia, en la Amazonía baja del Perú hasta
los 800 msnm

DESCRIPCIÓN Liana silvestre y cultivada. Tiene espinas poco curvadas, son tomentosas en las ramas jóvenes, y glabras en las viejas. Hojas con peciolos cortos, oval-aovadas, envés tomentoso. Flores con pedúnculos pubescentes, 3 a 5 ramas con numerosas cabezuelas, flores sésiles, corola de 4.5 a 6 mms. Cáliz de 2mm, estilo glabro de 6.5 a 9 mm, estigma capituliforme. Frutos en cápsula de 6 a 8 cms y semillas de 2 a 3 mm.

USOS TRADICIONALES Contra el cáncer, Antiinflamatoria, contra la Artritis, Afrodisiaco, Diurética, Sarampión, Descensos, Limpieza de la sangre.

ESTUDIOS MODERNOS Reduce la inflamación, Reduce crecimiento de metástasis de melanoma, Modula el sistema inmunológico, anti viral, Artrosis, Anti Cáncer, Leucemia premielocítica HL60, Leucemia aguda linfoblástica, Reparación del ADN de la piel, Pantalla solar, Anti oxidante,  Mejora la memoria, Protege implantación fetal

TESTIMONIOS: Cáncer de pulmón.

FUENTES

Title: An ethanolic extract of Uncaria tomentosa reduces inflammation and B16-BL6 melanoma growth in C57BL/6 mice.
Author: Fazio,-A-L; Ballen,-D; Cesari,-I-M; Abad,-M-J; Arsenak,-M; Taylor,-P
Citation: Boletin-Latinoamericano-y-del-Caribe-de-Plantas-Medicinales-y-Aromaticas. 2008; 7(4): 218-224

Title: Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2.
Author: Reis,-S-R-I-N; Valente,-L-M-M; Sampaio,-A-L; Siani,-A-C; Gandini,-M; Azeredo,-E-L; D'Avila,-L-A; Mazzei,-J-L; Henriques,-M-das-G-M; Kubelka,-C-F
Citation: International-Immunopharmacology. 2008; 8(3): 468-476

Title: Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis.
Author: Hardin,-S-R
Citation: Complement-Ther-Clin-Pract. 2007 Feb; 13(1): 25-8

Title: Antiprolifeative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines.
Author: Garcia-Prado,-E; Garcia-Gimenez,-M-D; De-la-Puerta-Vazquez,-R; Espartero-Sanchez,-J-L; Saenz-Rodriguez,-M-T
Citation: Phytomedicine. 2007 Apr; 14(4): 280-4

Title: Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. CCEA
Author: Cheng,-A-C; Jian,-C-B; Huang,-Y-T; Lai,-C-S; Hsu,-P-C; Pan,-M-H
Citation: Food-Chem-Toxicol. 2007 Nov; 45(11): 2206-18

Title: Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.
Author: Bacher,-N; Tiefenthaler,-M; Sturm,-S; Stuppner,-H; Ausserlechner,-M-J; Kofler,-R; Konwalinka,-G
Citation: Br-J-Haematol. 2006 Mar; 132(5): 615-22

Title: A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin
Author: Mammone,-T; Akesson,-C; Gan,-D; Giampapa,-V; Pero,-R-W
Citation: Phytother-Res. 2006 Mar; 20(3): 178-83

Title: Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC.
Author: Pilarski,-R; Zielinski,-H; Ciesiolka,-D; Gulewicz,-K
Citation: J-Ethnopharmacol. 2006 Mar 8; 104(1-2): 18-23

Title: Medicinal plants from Peru: a review of plants as potential agents against cancer.
Author: Gonzales,-G-F; Valerio,-L-G Jr
Citation: Anticancer-Agents-Med-Chem. 2006 Sep; 6(5): 429-44

Title: Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.
Author: Sheng, Y : Bryngelsson, C : Pero, R W
Citation: J-Ethnopharmacol. 2000 Feb; 69(2): 115-26

Title: The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line.
Author: Riva, L : Coradini, D : Di Fronzo, G : De Feo, V : De Tommasi, N : De Simone, F : Pizza, C
Citation: Anticancer-Res. 2001 Jul-Aug; 21(4A): 2457-61

Title: Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test.
Author: Mohamed, A F : Matsumoto, K : Tabata, K : Takayama, H : Kitajima, M : Watanabe, H
Citation: J-Pharm-Pharmacol. 2000 Dec; 52(12): 1553-61

Title:Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato)
Author: Lemaire, I : Assinewe, V : Cano, P : Awang, D V : Arnason, J T
Citation: J-Ethnopharmacol. 1999 Feb; 64(2): 109-15

Title: Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.
Author: Sheng, Y : Pero, R W : Amiri, A : Bryngelsson, C
Citation: Anticancer-Res. 1998 Sep-Oct; 18(5A): 3363-8

Title: Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts.
Author: Rizzi, R : Re, F : Bianchi, A : De Feo, V : de Simone, F : Bianchi, L : Stivala, L A
Citation: J-Ethnopharmacol. 1993 Jan; 38(1): 63-77

Title: Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa.
Author: Aquino, R : De Feo, V : De Simone, F : Pizza, C : Cirino, G
Citation: J-Nat-Prod. 1991 Mar-Apr; 54(2): 453-9

Kelly León de Tesis de Pre Grado 2007 Univ. Nacional Mayor de San Marcos,  “fecto protector de la fracción fenólica de Uncaria tormentosa en embriones preimplantacionales de ratón”.